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Effects of the high dose of nicotine (0.36 mg/kg) on locomotor activity in open field (n=8). Adult mice (PND 53) showed decreased locomotor activity following 2 injections of 0.36 mg/kg with 15 day delay during adulthood. Error bars indicate Standard Error of the Mean (SEM) and asterisks represent differences from the saline group at the p<0.05 level.
