Table 2. Demographic and baseline characteristics of participants.
| All participants (N=5116) | Participants with normal cognition, MMSE ≥ 24 (n = 3,624) | Participants with cognitive impairment, MMSE < 24 (n = 1,492) | ||||
|---|---|---|---|---|---|---|
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| Mean ± S.D. or n and % | Range | Mean ± S.D. or n and % | Range | Mean ± S.D. or n and % | Range | |
| Quantitative (continuous) characteristics | ||||||
| Age (y) | 76.8 ± 7.7 | 60–101 | 76.6 ± 7.7 | 60–100 | 77.2 ± 7.9 | 60–101 |
| Education (y) | 14.7 ± 3.6 | 0–29 | 15.3 ± 3.1 | 2–29 | 13.3 ± 4.1 | 1–24 |
| Population density (people/sq. mile) | 7854.4 ±18069.4 | 2–145,460 | 7,834.5 ± 18,413 | 2–145,460 | 7,902.7 ± 17,202 | 2.4–145,460 |
| Baseline MMSE | 25.0 ± 4.9 | 1–30 | 28.5 ±1.58 | 18–30 | 24.2 ± 5.1 | 1–30 |
| Baseline CDR-SB | 3.0 ± 3.2 | 0–18 | 0.18 ±0.45 | 0–3.5 | 3.6 ± 3.2 | 0–18 |
| Qualitative (categorical) characteristics | ||||||
| Male | 2,401 (46.9%) | 1,711 (47.2%) | 690 (46.2%) | |||
| Race | ||||||
| White | 4,278 (83.8%) | 3,145 (86.8%) | 1,133 (75.9%) | |||
| Black | 613 (12.0%) | 374 (10.3%) | 239 (16.0%) | |||
| Other | 212 (4.2%) | 100 (2.8%) | 112 (7.5%) | |||
| APOE genotype | ||||||
| ε3/ε3 | 1,844 (36.0%) | 1,404 (38.7%) | 440 (29.5%) | |||
| ε3/ε4 | 1,515 (29.6%) | 1,013 (28.0%) | 502 (33.6%) | |||
| ε3/ε2 | 295 (5.8%) | 252 (7.0%) | 43 (2.9%) | |||
| ε4/ε4 | 383 (7.5%) | 231 (6.4%) | 152 (10.2%) | |||
| ε4/ε2 | 112 (2.2%) | 87 (2.4%) | 25 (1.7%) | |||
| ε2/ε2 | 10 (0.2%) | 8 (0.2%) | 2 (0.1%) | |||
| Presence of ≥ 1 APOE4 allele | 2,123 (48.3%) | 1,331 (36.7%) | 679 (45.5%) | |||
| Florida residents at baseline | 111 (2.1%) | 66 (1.90%) | 43 (2.9%) | |||
| Ever smoked, yes | 2,566 (47.4%) | 1,770 (48.8%) | 1705 (45.7%) | |||
| B12 deficient | 580 (10.7%) | 386 (10.7%) | 163 (10.9%) | |||