. Author manuscript; available in PMC: 2018 Jan 5.

Published in final edited form as: Int Rev Neurobiol. 2015 Sep 19;124:171–208. doi: 10.1016/bs.irn.2015.08.004

Table 1.

Effects of Acute Nicotine on Anxiety

Study	Strain/Species	Task	Nicotine Dose	Injection Time	Effect
Irvine, Cheeta, and File (2001)	Hooded Lister rats	EPM	0.1 mg/kg s.c.	30 min	Increased anxiety
Irvine, Cheeta, and File (2001)	Hooded Lister rats	EPM	0.1 mg/kg s.c.	5 min	Decreased anxiety
Ouagazzal, Kenny, and File (1999)	Hooded Lister rats	EPM	0.5 and 1 mg/kg i.p.	5 min	Increased anxiety
O’Neill and Brioni (1994)	Wistar rats	EPM	0.3 mg/kg i.p.	30 min	Decreased anxiety
Ericson, Olausson, Engel, and Söderpalm (2000)	CD1 mice	EPM	0.35 mg/kg s.c.	Immediate	Decreased anxiety
Irvine, Cheeta, and File (1999)	Hooded Lister rats	Social interaction	0.1 mg/kg s.c.	30 min	Decreased anxiety
Irvine, Cheeta, and File (1999)	Hooded Lister rats	Social interaction	0.1 mg/kg s.c.	5 min	Increased anxiety