Table 2.
Involvement of VGCCs in neurologic and psychiatric disorders.
| Channel | Disease/Symptom | Species |
|---|---|---|
| Cav1.2 | Autism/Timothy syndrome | Human [47] |
| Conditioned fear | Mouse [48] | |
| Depression/Mood disorders | Human, mouse [49,50] | |
| Febrile seizures | Rat [51] | |
| Multiple sclerosis | Mouse [46] | |
| Pain | Mouse, rat [52,53,54] | |
| Parkinson’s disease | Human, mouse (reviewed in [28]) | |
| Schizophrenia | Human [55] | |
| Cav1.3 | Deafness | Mouse [56,57] |
| Depression | Human, mouse [50,58] | |
| Pain | Rat [52,53] | |
| Parkinson’s disease | Human, mouse (reviewed in [28]) | |
| Cav1.4 | (Incomplete X-linked congenital stationary) night blindness | Human [59,60] |
| Cav2.1 | Episodic ataxia type 2 and familiar hemiplegic migraine type 1 | Human [61,62,63] |
| Spinocerebellar ataxia 6 | Human [64,65] | |
| Cav2.2 | Pain | Mouse [54] |
| Cav2.3 | Anxiety | Mouse [66] |
| Absence epilepsy | Mouse [66] | |
| Pain | Mouse [67] | |
| Cav3.1 | Thalamocortical network activity/ absence epilepsy | Mouse [68] |
| Cav3.1–3.3 | Autism/Autism spectrum disorders | Human [69] |
| Pain | Human, mouse, rat (reviewed in [70]) | |
| Parkinson’s disease/locomotor deficits | Rat [71] | |
| Various VGCCs | Alzheimer’s disease/dementia | Mouse, rat, human (reviewed in [72]) |