| Interpretable neoplastic spots | HER2-positive spots (%) | Hormone receptors status | HER2-heterogeneous cases |
| 6 | 5 (83) | positive | 10 |
| 6 | 5 (83) | negative | 1 |
| 6 | 4 (67) | positive | 7 |
| 6 | 4 (67) | negative | 1 |
| 6 | 2 (33) | negative | 1 |
| 6 | 1 (17) | positive | 1 |
| 5 | 3 (60) | positive | 10 |
| 5 | 1 (20) | positive | 2 |
| 4 | 3 (75) | positive | 9 |
| 4 | 2 (50) | positive | 8 |
| 4 | 1 (25) | negative | 1 |
| 3 | 2 (67) | positive | 5 |
| 3 | 1 (33) | positive | 2 |
| 46 | 25 (54) | 53 (93) | 57 |
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