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Effect of modified U1 snRNA on splicing of KCNH2 intron 9 using a luciferase reporter construct. (A) Diagram of the KCNH2 minigene luciferase reporter construct. (B) Diagram of the modified U1 snRNA that increases its complementarity to the 5′ splice site of KCNH2 intron 9 at the +4 and +6 positions. (C) Histogram showing the effect of modified U1 snRNA on luciferase activity (n=6-7, ***P < 0.001).
