Table 2.
Evaluation of clinical and pathological variables on five-year breast cancer-specific survival and overall survival by univariable and multivariable analysis
| Variable | Breast Cancer-Specific Survival | Overall Survival | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Univariable | Multivariable | Univariable | Multivariable | |||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
|
| ||||||||
| Clinical Tumor category | ||||||||
| T0–T2 | 1.00 (ref) | 0.093 | 1.00 (ref) | 0.31 | 1.00 (ref) | 0.045 | 1.00 (ref) | 0.34 |
| T3–T4 | 1.44 (0.94–2.22) | 1.28 (0.79–2.09) | 1.49 (1.00–2.21) | 1.24 (0.79–1.96) | ||||
|
| ||||||||
| Approximated Tumor biology | ||||||||
| HR-positive/HER2-negative | 1.00 (ref) | <0.0001 | 1.00 (ref) | 1.00 (ref) | <0.0001 | 1.00 (ref) | <0.0001 | |
| HER2 positive | 0.13 (0.05–0.37) | 0.25 (0.09–0.72) | <0.0001 | 0.28 (0.14–0.55) | 0.56 (0.28–1.14) | |||
| Triple negative | 1.82 (1.19–2.80) | 3.32 (2.07–5.32) | 1.68 (1.12–2.52) | 3.13 (1.99–4.92) | ||||
|
| ||||||||
| Pathologic Tumor category | ||||||||
| T0/Tis | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | ||||
| T1 | 2.96 (1.45–6.01) | <0.0001 | 2.40 (1.07–5.41) | 0.069 | 2.56 (1.36–4.83) | <0.0001 | 2.16 (1.05–4.47) | 0.044 |
| T2 | 5.26 (2.59–10.67) | 3.61 (1.52–8.57) | 4.53 (2.41–8.52) | 3.30 (1.52–7.16) | ||||
| T3 | 6.36 (2.78–14.51) | 3.03 (1.04–8.82) | 6.46 (3.14–13.33) | 3.20 (1.24–8.30) | ||||
| T4 | — | — | 4.87 (0.63–37.48) | 2.11 (0.23–19.30) | ||||
|
| ||||||||
| Pathologic Nodal category | ||||||||
| N0 | 1.00 (ref) | <0.0001 | 1.00 (ref) | 0.007 | 1.00 (ref) | <0.0001 | 1.00 (ref) | 0.0011 |
| N1 | 2.48 (1.34–4.60) | 1.54 (0.76–3.12) | 2.28 (1.30–3.97) | 1.51 (0.79–2.87) | ||||
| N2 | 4.60 (2.46–8.57) | 2.38 (1.11–5.14) | 4.04 (2.29–7.12) | 2.25 (1.11–4.57) | ||||
| N3 | 7.36 (3.55–15.25) | 4.21 (1.72–10.31) | 7.93 (4.20–14.97) | 4.56 (2.03–10.27) | ||||
|
| ||||||||
| pCR | ||||||||
| Residual disease | 1.00 (ref) | <0.0001 | 1.00 (ref) | <0.0001 | ||||
| pCR | 0.26 (0.12–0.53) | 0.30 (0.16–0.56) | ||||||
|
| ||||||||
| Surgery Performed | ||||||||
| BCS | 1.00 (ref) | 0.26 | 1.00 (ref) | 0.80 | 1.00 (ref) | 0.15 | 1.00 (ref) | 0.80 |
| Mastectomy | 1.29 (0.83–1.99) | 1.06 (0.67–1.70) | 1.34 (0.90–2.00) | 1.06 (0.68–1.63) | ||||
|
| ||||||||
| Radiation | ||||||||
| Yes | 1.00 (ref) | 0.96 | 1.00 (ref) | 0.20 | 1.00 (ref) | 0.94 | 1.00 (ref) | 0.21 |
| No | 0.98 (0.55–1.77) | 1.46 (0.82–2.61) | 1.02 (0.60–1.74) | 1.41 (0.82–2.42) | ||||
|
| ||||||||
| Residual Cancer Burden class | ||||||||
| 0 | 1.00 (ref) | <0.0001 | 1.00 (ref) | <0.0001 | ||||
| I | 2.17 (0.58–8.18) | 1.56 (0.44–5.60) | ||||||
| II | 2.13 (0.89–5.08) | 1.63 (0.75–3.56) | ||||||
| III | 7.75 (3.65–16.44) | 6.85 (3.58–13.10) | ||||||
Abbreviations: pCR = Pathologic complete response; BCS= breast conserving surgery; RCB=Residual cancer burden.