Figure 1.
Power to detect association, at genome-wide significance (P < 5 × 10−8), using alternative approaches to aggregate GWAS across diverse populations: fixed-effects meta-analysis; random-effects (RE2) meta-analysis; and meta-regression including axes of genetic variation as covariates as implemented in MR-MEGA. Power is presented as a function of the allelic odds-ratio for each of five scenarios for heterogeneity in effects between populations, described in Supplementary Material, Table S1.