Table 3.

Index SNPs for distinct T2D association signals at four susceptibility loci on the basis of aggregation of summary statistics from 18 GWAS (22,086 cases and 42,539 controls) from diverse populations using: (i) MR-MEGA meta-regression accounting for ancestry with three axes of genetic variation as covariates; and (ii) reported results from fixed-effects meta-analysis

Locus	Index SNP	Chr	Position	Alleles		MR-MEGA meta-regression			Fixed-effects meta-analysis
				Risk	Other	P-value	pHET-ANC	pHET-RES	OR (95% CI)	P-value	pQ
IGF2BP2	rs11705729	3	185,507,299	T	C	2.1 × 10−19	0.50	0.44	1.14 (1.11–1.17)	1.3 × 10−21	0.49
CDKAL1	rs9368222	6	20,686,996	A	C	5.1 × 10−31	0.00042	0.23	1.17 (1.14–1.21)	4.1 × 10−30	0.0058
CDKN2A-B	rs10965246	9	22,132,698	T	C	4.8 × 10−37	0.62	0.0012	1.31 (1.26–1.36)	8.4 × 10−40	0.0029
	rs10757282	9	22,133,984	C	T	3.9 × 10−11	0.16	0.24	1.12 (1.09–1.16)	2.0 × 10−12	0.17
KCNQ1	rs231353	11	2,709,019	G	A	2.7 × 10−9	0.92	0.64	1.11 (1.07–1.14)	1.7 × 10−11	0.79
	rs233448	11	2,840,424	C	T	3.9 × 10−10	0.34	0.17	1.12 (1.09–1.16)	9.5 × 10−12	0.18
	rs2237897	11	2,858,546	C	T	2.9 × 10−10	0.33	0.36	1.19 (1.14–1.26)	7.7 × 10−12	0.35

Chr: chromosome. OR: odds-ratio. CI: confidence interval. p_HET-ANC: P-value for heterogeneity correlated with ancestry. p_HET-RES: P-value for residual heterogeneity. p_Q: Cochran’s Q statistic P-value.