Table 2. Assessment of interaction between Ki67 indices and clinico-pathological variables.

RS	Ki67 Index (Whole-slide)	P Value	Ki67 Index (Hot-spot)	P Value
Low	6.86	Int. vs Low = 0.012	15.84	Int. vs Low = 0.005
Intermediate	8.33	High vs Low < 0.001	19.21	High vs Low < 0.001
High	20.21	High vs Int. < 0.001	43.66	High vs Int. < 0.001
Tumor Grade
1	8.15	2 vs 1 = 0.297	16.49	2 vs 1 = 0.704
2	6.53	3 vs 1 < 0.001	16.08	3 vs 1 < 0.001
3	7.46	3 vs 2 < 0.001	33.88	3 vs 2 < 0.001
ER Score
ER<5	16.96	0.004	36.98	0.002
ER = 5	7.05		16.46
PgR Score
PgR<5	8.98	0.012	20.63	0.008
PgR = 5	6.66		15.27
Nuclear Grade
1	7.11	2 vs 1 = 0.555	17.10	2 vs 1 = 0.232
2	6.85	3 vs 1 = 0.046	16.06	3 vs 1 = 0.129
3	10.5	3 vs 2 < 0.001	23.83	3 vs 2 < 0.001
Mitotic Score
1	6.63	2 vs 1 < 0.001	15.68	2 vs 1 < 0.001
2	11.95	3 vs 1 < 0.001	25.99	3 vs 1 < 0.001
3	17.54	3 vs 2 = 0.005	35.93	3 vs 2 = 0.008

RS, recurrence score; Int, intermediate-risk group; ER, estrogen receptor; PgR, progesterone receptor.