Table 3. Incidence of dementia and Cox model results for the ARD patient group and comparison group.
| Characteristics | N | Event (%) | Incidence§ | Adjusted HRa (95%CI) | |
|---|---|---|---|---|---|
| All | |||||
| Comparison group | 138640 | 4280 | (3.09) | 48.43 | 1.00 |
| All ARD patients | 34660 | 1305 | (3.77) | 63.08 | 1.23 (1.15–1.31)*** |
| RA | 19556 | 713 | (3.65) | 58.07 | 1.14 (1.06–1.32)** |
| SLE | 3062 | 82 | (2.68) | 46.32 | 1.07 (0.86–1.34) |
| SS | 8449 | 408 | (4.83) | 87.11 | 1.46 (1.32–1.63)*** |
| Primary SS | 4756 | 238 | (5.00) | 95.96 | 1.35 (1.18–1.54)*** |
| Secondary SS | 3693 | 170 | (4.60) | 77.14 | 1.67 (1.43–1.95)*** |
| Other ARDs | 3593 | 102 | (2.84) | 52.11 | 1.21 (0.99–1.48) |
| Age < 65 | |||||
| Comparison group | 96722 | 828 | (0.86) | 12.98 | 1.00 |
| All ARD patients | 24188 | 259 | (1.07) | 16.81 | 1.16 (1.00–1.33)* |
| RA | 13417 | 142 | (0.79) | 15.78 | 1.08 (0.90–1.29) |
| SLE | 2299 | 17 | (0.74) | 11.70 | 0.88 (0.54–1.42) |
| SS | 5802 | 79 | (1.36) | 23.47 | 1.57(1.24–1.98) *** |
| Primary SS | 3057 | 37 | (1.21) | 22.39 | 1.49(1.07–2.07)* |
| Secondary SS | 2745 | 42 | (1.53) | 24.51 | 1.64 (1.20–2.25)** |
| Other ARDs | 2670 | 21 | (0.79) | 13.23 | 0.95 (0.61–1.47) |
| Age ≥ 65 | |||||
| Comparison group | 41918 | 3452 | (8.24) | 140.50 | 1.00 |
| All ARD patients | 10472 | 1046 | (9.99) | 198.00 | 1.25 (1.16–1.34)*** |
| RA | 6139 | 571 | (9.30) | 174.17 | 1.15 (1.06–1.26)** |
| SLE | 763 | 65 | (8.52) | 205.06 | 1.19 (0.93–1.53) |
| SS | 2647 | 329 | (12.43) | 249.74 | 1.45(1.30–1.63) *** |
| Primary SS | 1699 | 201 | (11.83) | 242.92 | 1.35 (1.17–1.55)*** |
| Secondary SS | 948 | 128 | (13.50) | 261.27 | 1.66 (1.39–1.99)*** |
| Other ARDs | 923 | 81 | (8.52) | 218.88 | 1.33 (1.06–1.66)* |
§ Incidence per 10,000 person-years
*: p value for HR < 0.05
**: p value for HR < 0.01
***: p value for HR < 0.001
a HR adjusted by age group, sex, and comorbidities