Table 2. Evaluation of heart function, weight, and systemic blood pressure in aged mice.
| pRb Het | pRb cKO | |||
|---|---|---|---|---|
| Female (n) | Male (n) | Female (n) | Male (n) | |
| Heart Rate (beats/min) | 702 ± 52 (3) | 595 ± 20 (5) | 615 ± 55 (4) | 609 ±72 (4) |
| EF (%) | 66.38 ±5.39 (3) | 60.28 ±3.88 (5) | 68.16 ±7.74 (4) | 59.38 ±3.66 (4) |
| FS (%) | 36.25 ±3.89 (3) | 32.14 ±2.73 (5) | 38.62 ±5.61 (4) | 31.46 ±2.43 (4) |
| Systolic BP | 112.73 ±7.06 (3) | 134.83 ±6.74 (5) | 115.23 ±4.81 (4) | 122.21 ±2.85 (4) |
| Diastolic BP | 78.05 ±4.43 (3) | 95.60 ±3.19 (5) | 80.96 ±2.95 (4) | 84.20 ±3.54 (4) |
| Normalized Heart Weight (mg/mm) | 87.11 ±3.5 (8) | 119.2 ±5.2 (7) | 112.8 ±10.8 * (4) | 147.3 ±5.8 ** (7) |
EF, ejection fraction; FS, fractional shortening; BP, blood pressure. Heart weight normalized to tibia length. Values shown are mean ± SD. T-test:
*P-value = 0.016,
**P-value = 0.0036;
sex-matched cKO compared to Het.