Skip to main content
. 2017 Sep 27;97(1):108–117. doi: 10.1177/0022034517732538

Figure 1.

Figure 1.

Tmem107–/– mutants display multiple gross morphological defects in craniofacial regions. E12.5, Tmem107–/– embryos (I, I′, J) exhibit exencephaly and altered morphology of the rostrum in comparison to wild-type (wt) animals (A, A′, B). At E13.5, Tmem107–/– mutants display cleft lip and palate (K′, L), in comparison to wt controls (C, C′, D). At E14.5, Tmem107–/– embryos display shorter snouts (M) together with cleft lip and palate (N) in contrast to wt animals (E, F). At E15.5, Tmem107–/– mutants show altered morphology of snout, together with cleft lip and palate (O′, P), compared to wt mice (G, G′, H). At all stages examined, Tmem107–/– embryos displayed reduced or absent eyes. Scale bar = 1 mm.