. 2018 Jan 5;13(1):e0190882. doi: 10.1371/journal.pone.0190882

Table 3. Zero-inflated count regression models results.

	Total potential DDIs (ZINB Model)		Serious potential DDIs (ZIP Model)		Significant potential DDIs (ZINB Model)		Minor potential DDIs (ZIP Model)
Covariate (Count Equation-Not always 0)	exp (β) n = 556	p value	exp (β) n = 154	p value	exp (β) n = 475	p value	exp (β) n = 387	p value
Gender
Male	Ref	-	-	-	-	-	-	-
Female	1.18	0.013^*	1.23	0.146	1.21	0.010^*	1.01	0.897
Age (months)	1.001	0.018^*	1.00	0.810	1.001	0.047^*	1.001	0.038^*
BMI Z-score	0.99	0.586	1.04	0.279	0.99	0.829	0.99	0.994
Days of stay	0.96	0.004^*	0.98	0.265	0.96	0.005^*	0.98	0.022^*
Number of administered drugs	1.22	0.000^*	1.08	0.000^*	1.20	0.000^*	1.12	0.000^*
Presence of ADRs
No	Ref	-	-	-	-	-	-	-
Yes	0.92	0.457	1.14	0.491	0.87	0.224	1.19	0.065
Diagnoses
Other^a	Ref	-	-	-	-	-	-	-
C00-D48 Neoplasms	0.67	0.001^*	0.65	0.088	0.59	0.000^*	0.75	0.007^*
Q00-Q99 Congenital malformations	1.24	0.019^*	1.36	0.089	1.32	0.005^*	1.10	0.333
D50-D89 Dis. of Blood, Blood-forming Organs and Immunity	0.76	0.041^*	0.71	0.308	0.78	0.094	0.79	0.136
G00-G99 Dis. of Nervous System	1.31	0.029^*	0.88	0.641	1.08	0.537	1.57	0.000^*
Covariate (Binary Equation- Always 0)	exp (β) n = 359	p value	exp (β) n = 359	p value	exp (β) n = 359	p value	exp (β) n = 359	p value
Gender
Male	Ref	-	-	-	-	-	-	-
Female	0.86	0.610	1.15	0.837	1.26	0.553	0.49	0.056
Age (months)	0.99	0.710	0.98	0.003^*	0.99	0.814	0.99	0.412
BMI Z-score	0.99	0.958	0.88	0.458	1.04	0.552	1.04	0.676
Days of stay	1.09	0.171	0.95	0.713	1.14	0.167	1.08	0.325
Number of administered drugs	0.35	0.000^*	0.21	0.000^*	0.19	0.000^*	0.28	0.000^*
Presence of ADRs
No	Ref	-	-	-	-	-	-	-
Yes	1.78	0.335	2.06	0.498	5.69	0.040^*	1.60	0.504
Diagnoses
Other^a	Ref	-	-	-	-	-	-	-
C00-D48 Neoplasms	1.26	0.694	17.07	0.027^*	1.46	0.641	0.95	0.942
Q00-Q99 Congenital malformations	0.31	0.003^*	0.31	0.192	0.21	0.003^*	0.35	0.049^*
D50-D89 Dis. of Blood, Blood-forming Organs and Immunity	1.08	0.834	3.42	0.270	0.77	0.631	1.31	0.619
G00-G99 Dis. of Nervous System	0.16	0.035^*	0.02	0.031^*	0.01	0.196	0.28	0.141

a: A00-B99 Infectious and Parasitic Dis., E00-E90 Endocrine, Nutritional and Metabolic Dis., F00-F99 Mental and Behavior Disord., H00-H59 Dis. Eye and Adnexa, I00-I99 Dis. Circulatory Syst., J00-J99 Dis. Respiratory Syst., K00-K93 Dis. Digestive Syst., L00-L99 Dis. Skin, M00-M99 Dis. Musculoskeletal Syst., N00-N99 Dis. Genitourinary Syst., P00-P96 Perinatal Origin, R00-R99 Not classified, S00-T98 Trauma, Poisoning and external cause, V01-Y98 External causes of morbidity-mortality, Z00-Z99 Health services.

* p < 0.05.