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. 2017 Dec 21;13(12):e1005853. doi: 10.1371/journal.pcbi.1005853

Fig 2. Spike frequency adaptation response to applied depolarizing current.

Fig 2

A. Applied 0.1 nA depolarizing pulse. B. Simulated membrane potential during the pulse. C. M-type potassium current dynamics showing an increase in response to initial depolarization followed by a new, elevated steady state during stimulation. D. Intracellular calcium concentration [Ca2+]i. E. Calcium-activated SK-type potassium current. [Ca2+]i and SK-type potassium current are both involved in the change in firing rate during depolarizing stimuli. F. Firing frequency.