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. 2017 Dec 21;13(12):e1005853. doi: 10.1371/journal.pcbi.1005853

Fig 5. Comparison of simulated chemosensitive behavior and intracellular recordings.

Fig 5

Effect of hypocapnia and hypercapnia on the spontaneous firing rate in locus coeruleus (LC) neurons from rats. A. Hypocapnic alkalosis (2.5% CO2, pHo = 7.55, pHi = 7.3). B. Normocapnia (5% CO2, pHo = 7.45, pHi = 7.23); C. Hypercapnia (10% CO2, pHo = 7.15, pHi = 7.4); D. Hypercapnic acidosis (15%CO2, pHo = 7, pHi = 6.96). Traces of membrane potential (Vm) vs. time showing action potential frequency from experimental data (black) and model-generated data (colored) for different conditions. Experimental traces were redrawn from data from Li and Putnam (2013) [45].