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. 2017 Dec 21;13(12):e1005853. doi: 10.1371/journal.pcbi.1005853

Fig 8. Firing frequency response to different electrical and chemical stimuli.

Fig 8

A. Simulated membrane potential for different chemical stimuli: control (normocapnic: 5% CO2, pHo = 7.45, pHi = 7.25), isohydric hypercapnia (IH: 15% CO2, pHo = 7.45, pHi = 7.25), isocapnic acidosis (IA: 5% CO2, pHo = 7.1, pHi = 7.0), and hypercapnic acidosis (HA: 15% CO2, pHo = 7.1, pHi = 7.0). B. Firing rate under normocapnia (grey bar) and the same chemical stimuli as in A (blue bars) at different values of external applied current: excitatory stimulus current, Is < 0; spontaneously firing neuron, Is = 0; and inhibitory stimulus current, Is > 0. C. Sensitivity for each chemical stimulus was calculated as the percentage increase from control firing rate.