Table 1. Experimental and calculated values for electrophysiological properties.
Basic characteristics of action potential | Average chemosensitive response | ||||
---|---|---|---|---|---|
Thresh.(mV) | AHP (mV) | Amplitude (mV) | Initial FR (Hz) | % Change in FR (HA) | |
Exp. | -48.5 ± 6.4 | 17.5 ± 2.5 | 76.3 ± 5.7 | 1.75 ± 1.25 | 119.5 |
Model | -50.3 ± 4.6 | 16.7 ± 2.2 | 70 ± 4.5 | 1.43 ± 2.19 | 99.3 |
Average values obtained with the neuron model in accordance with experimental data (Exp.) from spontaneous action potentials of LC chemosensitive neurons. Threshold, afterhyperpolarization (AHP), amplitude, initial firing rate (FR) and the percentage increase in FR at hypercapnic acidosis (HA). Experimental values were averaged with those taken from [18,29,43].