Table 1. Details of Janssen Bioactivity Assays Used in This Studya.
| mGlu receptor | species | assay details |
|---|---|---|
| 1 | H | agonist and antagonist Ca2+ response |
| 2 | H | PAM GTPγS, PAM Ca2+, Ag GTPγS, and antagonist Ca2+ |
| 3 | H | agonist and antagonist Ca2+ response |
| 4 | H | agonist and antagonist GTPγS response |
| 5 | H | PAM and agonist Ca2+ response |
| 6 | R | agonist and antagonist GTPγS response |
| 7 | H | agonist and antagonist Ca2+ response |
| 8 | H | agonist and antagonist Ca2+ response |
a
Abbreviations: human (H), rat (R), positive allosteric modulator (PAM), guanosine 5′-O-[gamma-thio]triphosphate (GTPγS), calcium (Ca2+.)