Table 3. mGlu Receptor Allosteric Modulator Binding Site Amino Acids Used for PCM^a.

TM2	TM3	TM4	ECL2b	TM5	TM6	TM7
2.46a.42c	3.28a.32c	4.53a43c	45.5	5.40a.40c	6.44a.46c	7.35a.29c
2.49a.45c	3.29a.33c		45.52	5.43a.43c	6.47a.49c	7.38a.32c
2.50a.46c	3.32a.36c			5.44a.44c	6.48a.50c	7.41a.35c
2.53a.49c	3.33a.37c			5.47a.47c	6.51a.53c	7.42a.36c
2.56a.52c	3.35a.39c			5.51a.51c	6.55a.57c	7.45a.39c
2.60a.56c	3.36a.40c					7.46a40c
	3.39a.43c					7.49a.43c
	3.40a.44c

^aAmino acids are identified by their adapted Ballesteros-Weinstein numbering according to recent recommendations.³⁷

^bBased on loop naming nomenclature from http://gpcrdb.org/.