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Acute toxicity dose 2000 mg/kg (P.O). Initial observation (Day-I) (n = 3).
| Parameters observed | I h | II h | III h | IV h |
|---|---|---|---|---|
| Piloerection | − | − | − | − |
| Oedema | − | − | − | − |
| Urine stains | − | − | − | − |
| Alopecia | − | − | − | − |
| Loss of writing reflex | − | − | − | − |
| Circling | − | − | − | − |
| Nasal sniffing | − | + | + | + |
| Lacrimation | − | − | − | − |
| Seizures | − | − | + | + |
| Righting reflex | + | − | + | + |
| Grip strength | + | − | − | − |
| Eye closure at touch | + | + | + | + |
| Rearing | + | − | − | − |
| Straub tail | − | − | − | − |
+: Presence.
−: Absence.
