Table 2.

Substrate scope for trans-(1R,2R)-selective Mb variants.^[a]

Product	Catalyst[b]	Conv. [%]	TON	de [%]	ee [%]
R1 = 4-CH3 (4b)	RR5	>99[c]	165	96	63
4-MeO (5b)	RR5	95[c]	160	97	74
4-Cl (6b)	RR2	>99	>500	97	49
4-CF3 (7b)	RR4	45[c]	75	97	64
3-Me (8b)	RR4	>99	>500	92	84
2-Me (9b)	RR3	>99	>500	>99	>99
10b	RR3	>99[c]	165	78	78
11b	RR4	45[c]	75	80	88
12b	RR2	84	420	96	65
13b	RR2	78	390	88	67
14b	RR1	56[c]	95	99	98
15b	RR4	54[c]	90	65	71

^[a]Reactions conditions: 20 μM Mb variant (0.2 mol%), 10 mM styrene, 20 mM EDA, 10 mM dithionite, 16 h.

^[b]For nomenclature of ‘RR1-5’ variants, see Figure 1 and Table S3.

^[c]Using 0.6 mol% Mb catalyst.