Table 3.
Effect of DAE and DHE on level of antioxidant enzymes and lipid peroxidation (TBARS) in diabetic-nephropathy Wistar rats.
| Parameters → |
SOD (U/mg protein) |
GSH (μM/mg protein) |
TBARS (nmol/mg protein) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Groups ↓ | Kidney | Pancreas | Liver | Kidney | Pancreas | Liver | Kidney | Pancreas | Liver |
| Normal | 3.87 ± 0.08 | 3.77 ± 0.15 | 4.22 ± 0.06 | 70.94 ± 0.472 | 67.62 ± 0.285 | 76.22 ± 0.477 | 0.55 ± 0.02 | 0.49 ± 0.01 | 0.65 ± 0.01 |
| Diabetic control | 1.24 ± 0.03a | 1.24 ± 0.03 a | 1.16 ± 0.04 a | 35.27 ± 0.438 a | 40.40 ± 0.438a | 41.37 ± 0.336 a | 2.27 ± 0.03 a | 2.25 ± 0.03 a | 2.69 ± 0.02 a |
| DAE 100 mg/kg | 1.82 ± 0.02 a, b | 1.60 ± 0.02 a | 1.29 ± 0.01 a | 40.91 ± 0.968 a, b | 42.05 ± 0.645a | 45.70 ± 0.499 a, b | 2.07 ± 0.02 a, b | 1.97 ± 0.02 a, b | 2.49 ± 0.02 a, b |
| DAE 200 mg/kg | 2.31 ± 0.03 a, b, c | 2.50 ± 0.06 a, b, c | 2.25 ± 0.04 a, b, c | 53.08 ± 1.411 a, b, c | 52.14 ± 0.970 a, b, c | 51.86 ± 0.689 a, b, c | 1.93 ± 0.01 a, b, c | 1.51 ± 0.03 a, b, c | 2.10 ± 0.02 a, b, c |
| DAE 400 mg/kg | 3.53 ± 0.02a, b, c, d | 3.52 ± 0.05a, b, c, d | 3.32 ± 0.03a, b, c, d | 59.51 ± 0.563a, b, c, d | 58.93 ± 0.881a, b, c, d | 65.63 ± 0.727a,b, c, d, e | 1.60 ± 0.02a, b, c, d | 1.16 ± 0.02a, b, c, d | 1.66 ± 0.03a, b, c, d |
| DHE 100 mg/kg | 1.99 ± 0.01 a, b | 1.88 ± 0.02 a | 1.59 ± 0.04 a | 40.91 ± 0.968 a, b | 42.06 ± 0.646 a, b | 45.70 ± 0.499a | 1.97 ± 0.03 a, b | 1.77 ± 0.02 a, b | 2.22 ± 0.02 a, b |
| DHE 200 mg/kg | 2.54 ± 0.03 a, b, c | 2.63 ± 0.04 a, b, c | 2.53 ± 0.05 a, b, c | 53.08 ± 1.411 a, b, c | 52.15 ± 0.970 a, b, c | 50.20 ± 2.042 a, b, c | 1.73 ± 0.01 a, b, c | 1.31 ± 0.03 a, b, c | 1.90 ± 0.02 a, b, c |
| DHE 400 mg/kg | 3.73 ± 0.02a, b, c, d | 3.69 ± 0.03a, b, c, d | 3.61 ± 0.03a, b, c, d | 59.51 ± 0.563a, b, c, d | 58.94 ± 0.881a, b, c, d | 65.63 ± 0.727a,b, c, d, e | 1.40 ± 0.02a,b, c, d, e | 1.03 ± 0.01a, b, c, d | 1.36 ± 0.03a,b, c, d, e |
| Glimepride 10 mg/kg | 3.41 ± 0.03 a, b | 3.49 ± 0.04 a, b | 3.55 ± 0.04 a, b | 60.51 ± 0.488 a, b | 57.78 ± 0.605 a, b | 61.59 ± 0.553 a, b | 1.69 ± 0.03 a, b | 1.05 ± 0.03 a, b | 1.54 ± 0.03 a, b |
Each group (n = 6) represents Mean ± SEM. Data was analyzed by using One-way ANOVA followed by Tukey's multiple test (p < 0.05); a vs control, b vs Diabetic control, c vs D. indica extract 100 mg/kg, d vs D. indica extract 200 mg/kg, e vs glimepride 10 mg/kg.