Table 2. Cytokine levels in different groups and subgroups.

Cytokine concentrations (in pg/ml serum) for healthy dogs (n = 16), B. canis- infected dogs on the day 1 (n = 31) and 7 (n = 30) and subset of uncomplicated (n = 13) and complicated groups (n = 18). 1 dog with complications died during the study. p-values for significant differences are shown for each comparison.

	CONCENTRATION (pg / ml serum)
	GM-CSF	KC-like	IL-2	IL-7	IL-8	IL-10	IL-15	IL-18	MCP-1
Healthy (n = 16)
Min-Max	60–154	28–269	10–75	39–109	122–235	1–1	42–142	2–840	159–792
Median	87	39	17	55	137	1	77	83	193
SD	24	58	26	20	42	0	26	232	154
Diseased day 1 (n = 31)
Min-Max	130–782	104–2739	22–2514	31–1957	10–6502	1–2106	12–5436	2–2278	163–1921
Median	182	532	96	101	856	560	160	188	390
SD	176	639	525	378	1541	421	1032	487	494
p-value	< 0.0001	< 0.0001	< 0.0001	0.019	< 0.0001	< 0.0001	0.007	0,044	0,001
Diseased day 7 (n = 30)
Healthy(n = 16)
Min-Max	135–2822	110–2184	12–4038	35–3633	425–8818	1–548	29–5548	2–8748	156–7667
Median	196	561	49	80	2754	1	219	207	237
SD	544	602	774	706	2185	108	1089	1900	1434
p-value	< 0.0001	< 0.0001	0.014	0.1308	< 0.0001	0.321	0.007	0.029	0.09
Uncomplicated day 1 (n = 13)
Min-Max	130–220	104–969	22–187	31–119	35–5019	1–2106	12–342	2–490	163–436
Median	143	330	89	51	601	461	111	145	224
SD	29	282	44	26	1477	527	110	180	95
Complicated day 1 (n = 18)
Min-Max	131–782	162–2739	22–2514	35–1957	10–6502	180–1499	12–5436	2–2278	181–1921
Median	254	567	131	139	908	592	265	188	576
SD	198	749	665	470	1620	342	1324	610	552
p-value	0.00066	0.0322	0.025	0.00019	0.509	0.675	0.065	0.34683	0.00015
Uncomplicated day 7 (n = 13)
Min-Max	139–272	117–2009	12–276	39–183	1391–6294	1–1	29–1109	2–762	156–282
Median	154	440	28	68	2852	1	184	145	191
SD	44	474	87	48	1362	0	309	231	42
Complicated day 7 (n = 17)
Min-Max	135–2822	110–2184	12–4038	35–3633	425–8818	1–548	29–5548	2–8748	156–7667
Median	254	830	65	84	1911	1	253	225	365
SD	689	635	1005	917	2695	141	1406	2484	1844
p-value	0.059	0.04455	0.391	0.503	0.503	0.601	0.769	0.834	0.013