Figure 2.

XN (0.4 mg/kg) treatment preserves mouse visual function for several weeks following toxic light exposure. Scotopic ERG a-wave (A, C, E) and b-wave (B, D, F) amplitudes from 129SV mice at 1 (top), 2 (middle), and 4 weeks (bottom) after light exposure. Mice injected with vehicle and exposed to 50,000-lux light for 6 hours (open black circles, black dashed lines) exhibited the most severe decreases in a- and b-wave amplitude, whereas mice given XN and subjected to toxic light (open red squares, red dashed lines) exhibited partial a-wave and b-wave preservation as compared to vehicle and XN-treated mice exposed to 50 lux (filled black and red squares, respectively). For each treatment group n = 5,^a,b P < 0.05 versus all other groups.