Skip to main content
. 2017 Dec 26;15:347–362. doi: 10.1016/j.redox.2017.12.012

Fig. 5.

Fig. 5

Mito-metformin induces increased O2•–and H2O2formation in pancreatic cancer cells. O2•–-dependent oxidation of the HE probe (A) and H2O2-dependent oxidation of the probe, o-MitoPhB(OH)2 (B) in MiaPaCa-2 cells treated for 24 h with Mito-Met10. (Obtained from Refs. [55], [59]. Reprinted from Cancer Research, 76, G. Cheng, J. Zielonka, O. Ouari, M. Lopez, D. McAllister, K. Boyle, C.S. Barrios, J.J. Weber, B.D. Johnson, M. Hardy, M.B. Dwinell, B. Kalyanaraman, Mitochondria-targeted analogs of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells, 3904-15, Copyright 2016, and from Interface Focus, 7, B. Kalyanaraman, G. Cheng, M. Hardy, O. Ouari, A. Sikora, J. Zielonka, M. Dwinell, Mitochondria-targeted metformins: anti-tumor and redox signaling mechanisms, 20160109, Copyright 2017.).