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. Author manuscript; available in PMC: 2019 Jan 4.
Published in final edited form as: Mol Cell. 2017 Dec 21;69(1):62–74.e4. doi: 10.1016/j.molcel.2017.11.031

Figure 7. A unified activation mechanism for mRNA 3′ processing and splicing.

Figure 7

The solid red line with arrow indicates that CFIm helps to recruits CPSF through direct interactions and the dotted red line with arrow indicates that CFIm promotes CstF recruitment indirectly (A–B). The dotted grey lines indicate the lack of RE/D regions in the yeast Fip1 and Snp1 (C–D). UE: U-rich elements. CFIm25-68 is a dimer, but shown as a monomer due to space limitation (A). The blue arrows represent cleavage and the widths of the arrows represent the frequencies of PAS usage.