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. Author manuscript; available in PMC: 2018 Jan 26.
Published in final edited form as: Cytometry A. 2017 Jul 5;93(1):93–103. doi: 10.1002/cyto.a.23165

Figure 1. Overview of micro-RNA (miRNA) sequencing and functional analysis.

Figure 1

High throughput miRNA sequencing analysis was performed in both swine adipose tissue-derived mesenchymal stem cells (MSCs) and their daughter extracellular vesicles (EVs) (n=7 each). Differentially expression analysis was performed to identify miRNAs enriched in EVs. miRNA predicted targets of top 4 miRNAs enriched in Lean- and MetS- EVs (highest fold change) were identified using TargetScan. Functional pathway analysis of top 50 target genes of top 4 miRNAs enriched in Lean- and MetS- EVs (total 200 miRNAs each) was performed using FunRich.