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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Jul 5;80:74–82. doi: 10.1016/j.semcdb.2017.07.004

Figure 4. ROS Signaling in AiP and Regeneration in various model organisms.

Figure 4

Figure 4

(A) H2O2 attracts immune cells (hemocytes) to sites of wounding or damage in Drosophila. The left panel displays the signaling events in the undead AiP model. The right panel shows the signaling events after laser-induced tissue damage in Drosophila embryos.

(B) H2O2 signaling after wounding or amputation in several regeneration models indicated at the bottom of each panel.

Abbreviations used: TNF – Tumor Necrosis Factor; JNK – Jun N-terminal Kinase; Upd – Unpaired (Interleukin−6 homolog); Wnt – Wg and Int−1; FGF – Fibroblast Growth Factor; IL−11 – Interleukin 11; JAK/STAT – Janus Kinase/Signal Transducers and Activator of Transcription.