Table 3.
Metabolites that differentiate moderate- versus high-power athletes
| Metabolite | Sub-pathway | Fold change | Bonferroni p value |
|---|---|---|---|
| 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)* | Phospholipid metabolism | 0.577623 | 5.92E-11 |
| 1-palmitoyl-2-oleoyl-GPI (16:0/18:1)* | Phospholipid metabolism | 0.42177 | 1.10E-07 |
| Imidazole lactate | Histidine metabolism | 0.447699 | 1.88E-06 |
| 1-stearoyl-2-oleoyl-GPC (18:0/18:1) | Phospholipid metabolism | 0.279019 | 4.51E-06 |
| 1-linolenoyl-GPC (18:3)* | Lysolipid | 0.414819 | 1.10E-05 |
| 1-linoleoyl-2-linolenoyl-GPC (18:2/18:3)* | Phospholipid metabolism | 0.537975 | 1.11E-05 |
| 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) | Phospholipid metabolism | 0.447877 | 5.88E-05 |
| 1-palmitoyl-GPI (16:0) | Lysolipid | 0.438221 | 0.000101 |
| Indolelactate | Tryptophan metabolism | 0.30948 | 0.000178 |
| 3-methylxanthine | Xanthine metabolism | 0.788924 | 0.00021 |
| 1,2-dilinoleoyl-GPC (18:2/18:2) | Phospholipid metabolism | 0.324133 | 0.000225 |
| 1-lignoceroyl-GPC (24:0) | Lysolipid | 0.321129 | 0.000287 |
| 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) | Phospholipid metabolism | 0.222855 | 0.000322 |
| N-acetylcarnosine | Dipeptide derivative | − 0.33185 | 0.000873 |
| 1-stearoyl-2-oleoyl-GPI (18:0/18:1)* | Phospholipid metabolism | 0.346165 | 0.001026 |
| N-acetylmethionine | Methionine, cysteine, SAM, and taurine metabolism | − 0.58119 | 0.001445 |
| 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) | Phospholipid metabolism | 0.153562 | 0.002983 |
| Argininate* | Urea cycle; arginine and proline metabolism | 0.422405 | 0.003294 |
| 7-methylxanthine | Xanthine metabolism | 0.648043 | 0.004023 |
| Homoarginine | Urea cycle; arginine and proline metabolism | − 0.27429 | 0.006606 |
| Gamma-glutamylvaline | Gamma-glutamyl amino acid | − 0.3052 | 0.008009 |
| Sphingosine 1-phosphate | Sphingolipid metabolism | − 0.20846 | 0.008168 |
| Phenyllactate (PLA) | Phenylalanine and tyrosine metabolism | 0.306398 | 0.009708 |
| Arabitol/xylitol | Pentose metabolism | 0.23942 | 0.015147 |
| 1-palmitoleoyl-GPC (16:1)* | Lysolipid | 0.229408 | 0.017685 |
| Methionine sulfone | Methionine, cysteine, SAM, and taurine metabolism | 0.308995 | 0.02004 |
| Guanidinoacetate | Creatine metabolism | − 0.22401 | 0.035446 |
| 1-stearoyl-2-linoleoyl-GPI (18:0/18:2) | Phospholipid metabolism | 0.261839 | 0.036305 |
| Sphingomyelin (d18:2/14:0, d18:1/14:1)* | Sphingolipid metabolism | 0.216635 | 0.036711 |
| 4-cholesten-3-one | Sterol | 0.242711 | 0.037246 |
| 1-palmitoyl-GPG (16:0)* | Lysolipid | 0.309379 | 0.040079 |
| Cholate | Primary bile acid metabolism | 1.182236 | 0.041373 |
| 1-palmitoyl-GPE (16:0) | Lysolipid | 0.230631 | 0.049265 |
| 1-stearoyl-2-linoleoyl-GPC (18:0/18:2)* | Phospholipid metabolism | 0.118022 | 0.052877 |
Asterisks (*) indicated on IDs of some metabolites refer to compounds that have not been officially confirmed based on a standard, but their identities are known with confidence