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. 2017 Oct 20;135(1):115–129. doi: 10.1007/s00401-017-1773-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Glioneuronal tumours cluster into two groups, which are only partially consistent with histology, according to their expression and methylation profiles. a Consensus clustering heatmap of 19 tumours (7 GG 6 DNET, 6 GNT NOS) and 7 controls. Cases are clustered according to the top 5000 most variably expressed genes. Group 1 consisted of 5 GG and 5 GNT NOS (n = 10). Group 2 consisted of 2 GG, 6 DNET, and 1 GNT NOS (n = 9). b Clustering heatmap of 65 tumours (34 GG, 11 DNET, 20 GNT NOS) and 6 controls. Cases are clustered according to the top 10,000 most variably methylated CpGs. Group 1 consisted of 19 GG, 1 DNET and 1 GNT NOS (n = 21). Group 2 consisted of 2 GG, 8 DNET, and 6 GNT NOS (n = 16)