Table 7.

Gene set enrichment analysis for neural-cell-type specific gene sets

Gene Set	Size	ES	NES	p value	q value
Group 1 vs Control
ASTROCYTE	149	0.68	2.98	< 0.0005	< 0.0005
MICROGLIA	148	0.62	2.72	< 0.0005	< 0.0005
ENDOTHELIA	148	0.59	2.57	< 0.0005	< 0.0005
MO	149	− 0.73	− 3.31	< 0.0005	< 0.0005
NFO	148	− 0.69	− 3.13	< 0.0005	< 0.0005
NEURON	148	− 0.53	− 2.40	< 0.0005	< 0.0005
OPC	149	− 0.32	− 1.47	0.005	0.005
Group 2 vs Control
ENDOTHELIA	149	0.71	3.06	< 0.0005	< 0.0005
MICROGLIA	148	0.61	2.64	< 0.0005	< 0.0005
OPC	149	0.61	2.64	< 0.0005	< 0.0005
ASTROCYTE	149	0.39	1.68	< 0.0005	0.001
MO	149	− 0.63	− 2.71	< 0.0005	< 0.0005
NEURON	148	− 0.61	− 2.53	< 0.0005	< 0.0005
NFO	148	− 0.46	− 1.96	< 0.0005	< 0.0005
Group 1 vs Group 2
ASTROCYTE	149	0.61	2.74	< 0.0005	< 0.0005
NEURON	148	0.40	1.76	< 0.0005	< 0.0005
MO	149	− 0.37	− 1.64	< 0.0005	< 0.0005
NFO	148	− 0.52	− 2.28	< 0.0005	< 0.0005
ENDOTHELIA	149	− 0.52	− 2.32	< 0.0005	< 0.0005
OPC	149	− 0.72	− 3.22	< 0.0005	< 0.0005

ES enrichment score. NES normalised enrichment score. For these scores, the highest and lowest scores are the most strongly enriched within each of the groups being compared, respectively. MO mature oligodendrocyte. NFO newly formed oligodendrocyte. OPC oligodendrocyte precursor cell