Fig. 4.

Efficacy of Cu(CQ)₂ in animals bearing subcutaneous A2780-CP and U251 tumor xenographs. NRG mice with s.c. injected cell lines (see “Materials and methods”) where treatment with vehicle (SH buffer, ●), copper liposomes (liposomes prepared in 300-mM CuSO₄) (copper dose of 3.2 mg/kg, ■), or Cu(CQ)₂ (30 mg/kg, ▲). The liposomal lipid dose was 115.6 mg/kg. Treatments were given i.v. on Monday, Wednesday, and Friday for 2 weeks. a A2780-CP tumor growth in NRG mice (n = 8), dosing began on day 4 post-cell inoculation. b U251 tumor growth in NRG mice (n = 6), treatment began when tumors reached 50–100 mm³. Data is reported as mean ± SEM