Fig. 6.
Efficacy of disulfiram (DSF) in combination with Cu(CQ)2 and copper liposomes (liposomes prepared in 300-mM CuSO4) determined in NRG mice with s.c. A2780-CP tumors. Treatment with CuSO4-liposomes (Cu-lips) (copper does of 3.2 mg/kg ■), DSF (100 mg/kg ●), DSF and Cu-liposomes (100-mg/kg DSF and 3.2-mg/kg copper, ○), or DSF and Cu(CQ)2 (100-mg/kg DSF and 30-mg/kg Cu(CQ)2, □) was initiated 4 days after s.c. inoculation of the A2780-CP cells. Cu(CQ)2 and copper liposomes were dosed iv Monday, Wednesday, and Friday for 2 weeks and DSF was dosed orally (see “Materials and methods”) Monday to Friday for 2 weeks. a A2780-CP tumor growth in NRG mice (n = 13) and b tumor size on day 20 was determined as described in the “Materials and methods” data is reported as mean ± SEM