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. 2018 Jan 5;18:36. doi: 10.1186/s12885-017-3957-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of siRNA-mediated Notch3 inhibition on mouse PaSC activation. a Transfection of Notch 3 siRNA in mouse PaSCs activation after 48 h, the morphological changes in PaSCs. b Representative western blotting images showing the effect of siRNA-mediated Notch3 inhibition on PaSC activation markers, such as α-SMA, fibronectin and collagen I, and on the Notch target gene HES1; densitometry analyses of the blots are also shown. c RT-qPCR results showing the effect of siRNA-mediated Notch3 inhibition on PaSC activation markers, such as α-SMA, fibronectin and collagen I, and on the Notch target gene HES1 at the transcriptional level. Scale bars: 100 μm in (a). The data are presented as the mean ± SD, *P < 0.05, **P < 0.01, and ***P < 0.001; n = 4; Student’s t-test