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. 2018 Jan 6;18:46. doi: 10.1186/s12885-017-3907-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Overview of genetic changes in KEAP1-NRF2-CUL3 in TCGA-HNSCC patients. a Pie chart showing individual percentages of genetic alterations in the KEAP1-NRF2-CUL3 complex. b Bar chart showing the types and percentages of mutations of the KEAP1-NRF2-CUL3 complex. c cBioportal-predicted mutation maps (lollipop plots) showing the positions of mutations on the functional domains of KEAP1, NRF2, and CUL3 proteins. The colored lollipops show the positions of the mutations as identified by whole-exon sequencing