Table 2.
GO and KEGG pathway analysis of 17 KEAP1-NRF2-CUL3 axis regulated genes in HNSCC
| Term | p-value | Genes |
|---|---|---|
| GO_Biological Proceess (GO_BP) | ||
| GO:0044597~daunorubicin metabolic process | 3.22E-08 | AKR1C3, AKR1C2, AKR1B10, AKR1C1 |
| GO:0044598~doxorubicin metabolic process | 3.22E-08 | AKR1C3, AKR1C2, AKR1B10, AKR1C1 |
| GO:0055114~oxidation-reduction process | 3.29E-07 | AKR1C3, AKR1C2, G6PD, AKR1B10, OSGIN1, TXNRD1, AKR1C1, SRXN1 |
| GO:0071395~cellular response to jasmonic acid stimulus | 4.46E-06 | AKR1C3, AKR1C2, AKR1C1 |
| GO:0042448~progesterone metabolic process | 2.67E-05 | AKR1C3, AKR1C2, AKR1C1 |
| GO:0006979~response to oxidative stress | 1.18E-04 | GCLC, GCLM, SRXN1, SLC7A11 |
| GO:0008202~steroid metabolic process | 6.58E-04 | AKR1C3, AKR1C2, AKR1B10 |
| KEGG Pathway | ||
| hsa00480:Glutathione metabolism | 5.9956E-05 | GSTM3, G6PD, GCLC, GCLM |
| hsa00140:Steroid hormone biosynthesis | 0.00362777 | AKR1C3, AKR1C2, AKR1C1 |
| hsa00980:Metabolism of xenobiotics by cytochrome P450 | 0.00584594 | AKR1C2, GSTM3, AKR1C1 |