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. 2018 Jan 1;27(1):10–22. doi: 10.1089/scd.2017.0132

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© Pavel Simara et al. 2017; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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FIG. 5. — Cell cycle speed and genome stability during the reprogramming and differentiation processes. (A) Percentage of EdU-negative (G1 phase) cells among hiPSCs, hiPSC-derived ECs, and EC controls. Mean value (±SEM; n = 3). Asterisks indicate statistically significant (P < 0.05) decreases in the percentages of hiPSCs in G1 phase compared with their EC counterparts, as detected using Student's t-test. (B) Number of γH2AX foci per cell in hiPSCs, hiPSC-derived ECs and EC controls. The bar represents the median. Asterisks indicate statistically significant (P < 0.05) differences between hiPSCs and ECs, as confirmed by the Mann–Whitney test. (C) Cytogenetic data from hiPSC lines. Approximately 100% of cells possess a normal karyotype in hiPSC-PB and hiPSC-HU lines (passages 27 and 16, respectively). Representative aneuploid karyotype detected in 80% of cells in the hiPSC-HS line, in which a gain of chromosome 1 was observed (passage 17). EdU, 5-ethynyl-2′-deoxyuridine; γH2AX, phosphorylated histone H2AX.