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. 2016 Oct;24(10):1786–1794. doi: 10.1016/j.joca.2016.05.019

Fig. 2.

Fig. 2

Control and ACLT Chondrocyte Swell Data. Changes in cell (chondrocyte) cross-sectional area in cells from sham (blue circles), and ACLT after 2 weeks (ACLT 2W, yellow circles) and 4 weeks (ACLT 4W, red triangles). Isotonic (360 mOsm) solution was changed to hypotonic solution (180 mOsm) at time 0s. Exposure of chondrocytes to hyposmotic solution led to a rapid increase in relative cell size (6% swell; i.e., 1.06, 95% CI 1.021–1.099 at 5 min, n = 15, N = 5) in control cells, and this swell was significantly greater with cells from ACLT 2W and 4W tissue (ACLT 2wk; 1.08, 95% CI 1.060–1.020 at 5 min, n = 21, N = 5, P ≤ 0.0005: ACLT 4wk; 1.11, 95% CI 1.071–1.149 at 5 min, n = 11, N = 5, P ≤ 0.0005. There was no significant change in absolute initial volumes (control 875, 95% CI 848–902 μm; ACLT 2wk 726, 95% CI 707–745 μm and ACLT 4wk 935, 95% CI 915–955 μm). All P-values were obtained from Dunnett's post-hoc multiple comparison against control).