Fig. 7.
Boltzmann analysis of control and 4W ACLT difference currents: Boltzmann curves created from the Control (blue circles) and 4W ACLT (red circles) chondrocyte difference current data shown in Fig. 4, Fig. 5. The smooth lines are fits with the Boltzmann curves with parameters as follows: For control; Vh 68 (95% CI 58.2–77.8) mV, slope 31 (95% CI 23.16–58.84) mV, maximum conductance 1035 (95% CI 935–1135) pS/pF. For 4W ACLT curves the mean fitted parameters were: Vh 7 (95% CI −2.8 to 16.8) mV, slope 24 (20.8–27.92) mV, maximum conductance 2290 (2200–2380) pS/pF. Slope was not significantly different from control (P = 0.19), but both midpoint and maximum conductance were P ≤ 0.0005 for each). Note that these P-values are Benjamini–Hochberg adjusted.