Table 3.

Process parameters for erythritol production of the discussed genetically modified microorganisms

Microorganism	Genetic modification	Substrate	Concentration (g/l)	Yield (g/g)	Productivity (g/l/h)	Reference
Yeast
T. megachiliensis SN-G42	Mutagenesis	Glucose	164.8	nd1	2	(Ishizuka et al. 1989), (Sawada et al. 2009)
C. magnoliae JH110	Mutagenesis	Glucose	200	0.43	1.2	(Kohl et al. 2003)
C. magnoliae 12-2	Mutagenesis	Glucose	20.3	nd	nd	(Ghezelbash et al. 2014)
T. oedocephalis HOG1	Δhog1	Glucose	56.8	0.28	nd	(Li et al. 2016)
Y. lipolytica MK1U- pADUTSuc2	suc2	Sucrose	52	0.26	0.9	(Mirończuk et al. 2015)
Y. lipolytica AMM pADUTSuc2 92h	suc2	Sucrose	73	0.37	1.0	(Mirończuk et al. 2015)
Y. lipolytica AMM pADUTSuc2 144h	suc2	Sucrose	113.9	0.57	0.8	(Mirończuk et al. 2015)
Y. lipolytica AJD pADUTSuc2	suc2	Sucrose	59.5	0.32	0.9	(Mirończuk et al. 2015)
Y. lipolytica AIB pAD-UTGUT1	gut1	Sucrose and glycerol	82.2	0.55	0.87	(Rakicka et al. 2017)
Y. lipolytica AMM pAD-GND1	gnd1	Glycerol	40.2	0.4	0.43	(Mirończuk et al. 2017)
Y. lipolytica AMM pAD-ZWF1	zwf1	Glycerol	42.5	0.43	0.45	(Mirończuk et al. 2017)
Y. lipolytica AMM pAD-TLK1	tkl1	Glycerol	51.1	0.51	0.54	(Mirończuk et al. 2017)
Y. lipolytica ΔYALI0F01606g	eyk1	Glycerol	nd	0.49	0.59	(Carly et al. 2017)
Bacteria
O. oeni		Glucose	nd	nd	nd	(Ortiz et al. 2013)
L. sanfranciscencis		Glucose	nd	nd	nd	(Ortiz et al. 2013)
Synechocystis PCC6803	err1/e4pp	None2	nd	nd	nd	(van der Woude et al. 2016)
Filamentous fungi
T. reesei	err1	Wheat straw	nd	nd	nd	(Jovanovic et al. 2013)

¹nd means not determined

²The strain is cultivated under moderate intensity white-light illumination or high intensity illumination for production via photosynthesis