Fig. 3. Rev-erbα KO mice show pro-inflammatory responses to CS exposure.
Wild-type littermates and Rev-erbα KO mice were exposed to acute CS exposure for (A) 10 days or (B) sub-chronic for 30 days. Levels of pro-inflammatory mediators (IL-6, MCP-1 and KC) were measured in BAL fluid obtained from acute 10 d and 30 d air- or CS-exposed mice by ELISA. Some of the analyses were repeated based on availability of the samples to reproduce the findings. Data are shown as mean ± SEM, n=4–6 per group for one month Air and CS exposures, and n=3–8 per group except for Rev-erbα KO and Air n=2–4 per group for 10 days. P<0.059 vs WT Air group, and ***P<0.001 vs WT-Air or Rev-erbα KO-Air.