Table 1.

Demographics and Confocal microscopy results

Subject	Primary vs. Revision Rhytidectomy	Age/Sex	Smoker	Number of ENF (mm)	SNP	Sebaceous Glands	SP	CGRP	VIP	Mast Cell Degranulation	Capillaries
1	Primary	66 F	No	67.0	0	0	14	15	4	0	Normal
2	Primary	47 F	Yes	14.2	−1	−1	1	9	1	−1	Complex
3	Primary	56 F	No	50.8	0	0	7	1	0	0	Normal
4	Primary	42 F	No	99.2	0	0	4	15	0	0	Normal
5	Primary	53 F	No	40.6	0	0	1	8	0	0	Normal
6	Revision	64 F	No	13.8	−1	−2	0	3	1	−4	Irregular
7	Revision	65 F	No	17.0	−1	0	0	0	2	−3	Irregular
8	Revision	64 F	No	25.0	0	0	0	7	17	−1	Complex

F – female, ENF, epidermal nerve fiber, SNP – subepidermal neural plexus, SP – substance P, CGRP – calcitonin gene-related peptide, VIP – vasoactive intestinal peptide

Grading System (ENF, Sebaceous Glands): 0 (normal), −1 (mild loss), −2 (moderate loss), −3 (severe loss), −4 (no nerve), +1 (hyper)

Grading System (SNP): 0 (normal), −1 (mild thinning), −2 (moderate thinning), −3 (sparse), −4 (no nerve)

Grading System (Mast Cell Degranulation): 0 (none), −1 (minimal or <10%), −2 (moderate or <50%), −3 (diffuse or <75%)