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. Author manuscript; available in PMC: 2018 Jan 7.
Published in final edited form as: Immunol Rev. 2018 Jan;281(1):8–27. doi: 10.1111/imr.12621

FIGURE 1.

FIGURE 1

The 3 subfamilies of the IL-1 family. The number of amino acids is indicated at the end of each cytokine precursor. The IL-1 family consensus sequence AXD is indicated for each cytokine, and the 9 amino acids preceding the AXD site is indicated by a vertical bar. The vertical bar indicates the location of the optimal N-terminus. A red circle represents the members with primary pro-inflammatory properties, whereas a green circle represents cytokines that are anti-inflammatory. Because IL-1Ra has a signal peptide and is readily secreted, there is no AXD site. Adapted from6