Figure 5.
Impact of oral bolus treatment with EGCG on the hepatic expression of mitochondria-related transcription factors and co-factors in C57BL/6J mice. Mice were fasted for 7 h and then treated once daily with EGCG by oral gavage for three days. Mice were euthanasized 1 h after the last dose and hepatic mRNA levels and protein levels were determined by qRT-PCR and western blot, respectively. SIRT3, FOXO3a, and PGC1α play an important role in mitochondrial biogenesis and antioxidant response. Data represent the mean ± SEM of n = 11–18. Data were analyzed using one-way ANOVA with Dunnett’s post-test. An asterisk indicates p < 0.05 compared to control mice. The western blot images show representative data.