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Features suggestive of a neuropathic component to dry eye symptoms
| Discordance between DE symptoms and signs, with symptoms outweighing signs145 |
| Non-response to therapies that target the ocular surface and tears57 |
| Presence of chronic overlapping pain conditions58, 191, depression, anxiety65 |
| Specific descriptors including spontaneous burning pain, sensitivity to wind and light4, 66 |
| Persistent ocular pain after topical anesthesia (e.g. proparacaine)125 |
DE=dry eye
