Table 3.

Pharmacokinetic information on sufentanil in children [108–110, 114–116, 119, 120, 188, 189].

n	Age	Weight (kg)	Dose (µg/kg)	Route	CL (mL/min/kg)	t1/2 (min)	V (L/kg)	Comp	No of samples/ duration	Lab method	Remarks	Ref.
9	11.0 ± 10.8 days	3.24 ± 0.36	10–15	IV, bolus	6.7 ± 6.1*	737 ± 346*	4.15 ± 1.01*	3	24/ 20h	RIA [188]	Neonates 1–30 days	[108]
7	13.9 ± 9.1 months	8.7 ± 3.2	10–15	IV, bolus	18.1 ± 2.8*	214 ± 41	3.09 ± 0.95	3	24/ 20h	RIA [188]	Infants 1 month – 2 years	[108]
7	6.4 ± 3.2 years	21.0 ± 6.7	10–15	IV, bolus	16.9 ± 3.2*	140 ± 30	2.73 ± 0.50	3	24/ 20h	RIA [188]	Children 2–11 years	[108]
5	15.4 ± 1.9 years	58.4 ± 9.4	10–15	IV, bolus	13.1 ± 3.6	209 ± 23	2.75 ± 0.53	3	24/ 20h	RIA [188]	Adolescents 12–18 years	[108]
20	5.2 ± 1.7 years	19.1 ± 5.2	2.42 ± 0.67	IV, bolus	30.5 ± 8.8	97.0 ± 42.0	2.94 ± 0.63	2/ non	17/ 8h	RIA [188]	Surgical patients	[110]
1	7 days	3.0	10	IV, bolus	4.3	434	2.6	3	24/ 20h	RIA [188]	Case report, congestive heart failure	[109]
1	28 days		10	IV, bolus	18.8	160	3.2	3	24/ 20h	RIA [188]	Same patient	[109]
1	4 days	3.1	10	IV, bolus	6.7	332	2.9	3	24/ 20h	RIA [188]	Case report, congestive heart failure	[109]
1	20 days		10	IV, bolus	19.3	242	3.3	3	24/ 20h	RIA [188]	Same patient	[109]
1	2 days	3.3	10	IV, bolus	1.7	1140	2.7	3	24/ 20h	RIA [188]	Case report, congestive heart failure	[109]
1	27 days		10	IV, bolus	12.9	248	3.6	3	24/ 20h	RIA [188]	Same patient	[109]
1	17 years	76	3	IV, bolus	28.3	39	1.137	2	13/ 8h	RIA [188, 189]	Orthopedic surgery patient	[114]
1	10 years	45	2/ 4.44/h	IV, bolus, cont. (48h)	15.8	2940	24.2	2	20+19/ 48h + 24h	RIA [188]	Head trauma patient	[115]
41	4.05a) (0.18–17.4) years	14a) (3.2–80)	1.42a) (0.47–4.39)/h Total dose: 2197a) (621–47221) µg	IV, cont. 99a) (25–600) h	10.8	504a) (102–12300)		2	>3+10/ 24h+36h	HPLC-MS		[116]
6	11.7 ± 3.8 years	44.7 ± 12.9	3–5	IV, 1 min	16.4 ± 6.1b)	89.7 ± 15.7b)	1.65 ± 0.6b)	2/ non	11/ 3h	RIA	surgical patients	[119]
6	11.8 ± 1.7 years	28.7 ± 5.7*	3–5	IV, 1 min	12.8 ± 12.0b)	76.0 ± 32.8b)	1.28 ± 0.62b)	2/ non	11/ 3h	RIA	Chronic renal failure	[119]
7	5.2 ± 2.1 months	5.3 ± 1.1	15	IV, 1 min	27.5 ± 9.3	53 ± 15	1.6 ± 0.46*	2	10/ 2h	RIA	age < 10 months, not surface-cooled, pre-CPB	[120]
6	15.5 ± 5.2 months	8.9 ± 1.6	15	IV, 1 min	18.1 ± 10.7	55 ± 10	3.0 ± 1.35	2	10/ 2h	RIA	age > 10 months, not surface-cooled, pre-CPB	[120]
7	5.1 ± 3.4 months	5.3 ± 2.4	15	IV, 1 min	21.5 ± 5.0	120 ± 36*	3.7 ± 1.1	2	10/ 2h	RIA	age < 10 months, surface-cooled, pre-CPB	[120]

^a)median data (range)

^b)results were switched by mistake in the publication

Reported statistical significance is indicated as follows:

^*p < 0.05,

^**p < 0.005,

^***p < 0.001.