Table 2.
Univariate (Kaplan-Meier) and multivariate (Cox proportional hazard regression) survival analysis of patients with Barcelona Clinic Liver Cancer C hepatocellular carcinoma according to clinical and tumor variables
| Variable |
Univariate analysis |
Multivariate analysis |
||
| Survival time (mo) | P value | Hazard ratio (95%CI) | P value | |
| Age | ||||
| < 65 yr | 13.9 | 0.903 | - | - |
| ≥ 65 yr | 13.8 | |||
| Gender | ||||
| Male | 13 | 0.900 | - | - |
| Female | 14.2 | |||
| PS | ||||
| 0 | 10.3 | 0.128 | - | - |
| 1/2 | 13.9 | |||
| Diabetes | ||||
| No | 13 | 0.813 | - | - |
| Yes | 13.8 | |||
| Child-Pugh score | ||||
| A | 13.4 | 0.957 | - | - |
| B | 12.8 | |||
| N nodules | ||||
| Single | 13.8 | 0.776 | - | - |
| 2-3 | 13.4 | |||
| Multinodular/infiltrating | 13 | |||
| Tumor size | ||||
| ≤ 5 cm | 13.9 | 0.0221 | 1 | 0.275 |
| > 5 cm | 9.9 | 1.357 (0.784-2.349) | ||
| Macrovascular invasion | ||||
| No | 15.8 | 0.0141 | 1 | 0.866 |
| Yes | 9.5 | 1.095 (0.379-3.162) | ||
| Extrahepatic spread | ||||
| No | 11.2 | 0.274 | - | - |
| Yes | 6.7 | |||
| Macrovascular invasion and/or extrahepatic spread | ||||
| No | 13.8 | 0.0081 | 1 | 0.429 |
| Yes | 6.3 | 1.547 (0.523-4.571) | ||
| AFP | ||||
| ≤ 200 ng/mL | 15.8 | 0.00021 | 1 | 0.0061 |
| > 200 ng/mL | 6.3 | 2.194 (1.249-3.855) | ||
| DC | ||||
| No | 7.6 | < 0.00011 | 1 | < 0.00011 |
| Yes | 15.8 | 0.190 (0.098-0.367) | ||
| NIACE score | ||||
| ≤ 3 | 13.8 | 0.515 | - | - |
| > 3 | 6.7 | |||
1
Statistically significant results. PS: Performance status; AFP: Alpha-fetoprotein; DC: Disease control.