Table 3.
Multivariate Cox regression model including alphafetoprotein and disease control as time dependent covariates
| Variable |
Multivariate analysis |
|
| Hazard ratio (95%CI) | P value | |
| Macrovascular invasion | ||
| No | 1 | 0.917 |
| Yes | 1.066 (0.412-2.762) | |
| Macrovascular invasion and/or extrahepatic spread | ||
| No | 1 | 0.366 |
| Yes | 1.552 (0.584-4.124) | |
| Tumor size | ||
| ≤ 5 cm | 1 | 0.266 |
| > 5 cm | 1.369 (0.786-2.382) | |
| AFP (> 200 ng/mL vs ≤ 200 ng/mL) | ||
| < 6 mo | 5.073 (2.159-11.916) | 0.00021 |
| 7-12 mo | 0.948 (0.275-3.267) | 0.932 |
| > 12 mo | 1.698 (0.620-4.648) | 0.303 |
| DC (Yes vs No) | ||
| < 6 mo | 0.220 (0.075-0.650) | 0.096 |
| 7-12 mo | 0.463 (0.181-1.189) | 0.109 |
| > 12 mo | 0.110 (0.038-0.314) | < 0.00011 |
For all other variables single hazard ratios were reported.
1
Statistically significant results. AFP: Alphafetoprotein; DC: Disease control.