Table 5.
Univariate (Fisher’s exact test) and multivariate (binomial logistic regression) analysis of factors associated with the achievement of disease control in patients with Barcelona Clinic Liver Cancer C hepatocellular carcinoma
| Variable | DC (43) | No DC (67) |
Univariate analysis |
Multivariate analysis |
|
| P value | Odds ratio (95%CI) | P value | |||
| Age | |||||
| < 65 yr | 15 | 27 | 0.229 | - | |
| ≥ 65 yr | 28 | 40 | |||
| Gender | |||||
| Male | 35 | 56 | 0.471 | - | |
| Female | 8 | 11 | |||
| PS | |||||
| 0 | 37 | 60 | 0.06 | - | |
| 1/2 | 6 | 7 | |||
| Diabetes | |||||
| No | 34 | 53 | 0.653 | - | |
| Yes | 9 | 14 | |||
| Child-Pugh score | |||||
| A | 31 | 51 | 0.524 | - | |
| B | 12 | 16 | |||
| N nodules | |||||
| Single | 13 | 22 | 0.078 | ||
| 2-3 | 11 | 9 | - | ||
| Multinodular/infiltrating | 19 | 36 | |||
| Tumor size | |||||
| ≤ 5 cm | 30 | 26 | 0.0061 | 1 | 0.298 |
| > 5 cm | 13 | 41 | 0.617 (0.236-1.610) | ||
| Macrovascular invasion | |||||
| No | 32 | 28 | 0.00031 | - | - |
| Yes | 11 | 39 | |||
| Extrahepatic spread | |||||
| No | 40 | 51 | 0.021 | - | - |
| Yes | 3 | 16 | |||
| Macrovascular invasion and/or extrahepatic spread | |||||
| No | 29 | 20 | < 0.00011 | 1 | 0.0021 |
| Yes | 14 | 47 | 0.263 (0.111-0.622) | ||
| AFP | |||||
| ≤ 200 ng/mL | 35 | 39 | 0.0081 | 1 | 0.179 |
| > 200 ng/mL | 8 | 28 | 0.461 (0.169-1.258) | ||
| NIACE score | |||||
| ≤ 3 | 34 | 50 | 0.502 | - | |
| > 3 | 9 | 17 | |||
| Treatment after BCLC C diagnosis | |||||
| No | 4 | 18 | 0.041 | 1 | 0.270 |
| Yes | 39 | 49 | 0.531 (0.147-1.917) | ||
1
Statistically significant results. PS: Performance status; AFP: Alpha-fetoprotein; DC: Disease control.